Dual-modality endomicroscopy with co-registered fluorescence and phase contrast.
نویسندگان
چکیده
We describe a dual-modality laser scanning endomicroscope that provides simultaneous fluorescence contrast based on confocal laser endomicroscopy (CLE) and phase-gradient contrast based on scanning oblique back-scattering microscopy (sOBM). The probe consists of a 2.6mm-diameter micro-objective attached to a 30,000-core flexible fiber bundle. The dual contrasts are inherently co-registered, providing complementary information on labeled and un-labeled sample structure. Proof of principle demonstrations are presented with ex-vivo mouse colon tissue.
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ورودعنوان ژورنال:
- Biomedical optics express
دوره 7 9 شماره
صفحات -
تاریخ انتشار 2016